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The Roles of Proton-Sensing G-Protein-Coupled Receptors in Inflammation and Cancer

1 Sept 2024

Abstract excerpt

The precise regulation of pH homeostasis is crucial for normal physiology. However, in tissue microenvironments, it can be impacted by pathological conditions such as inflammation and cancer. Due to the overproduction and accumulation of acids (protons), the extracellular pH is characteristically more acidic in inflamed tissues and tumors in comparison to normal tissues. A family of proton-sensing...

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PMID: 39336742
DOI: 10.3390/genes15091151

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