Article

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> In the tumor microenvironment of glioblastoma, myeloid cells act as a double-edged sword—they are a major cellular component modulating the immune response while presenting a potential therapeutic target. Our study highlights the voltage-gated proton channel Hv1, predominantly expressed in myeloid cells, as a crucial regulator of their physiological functions. We discovered a strong correlation...

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Literature Corpus work: 2baab3b4-5564-58d2-8155-5ea62f23768f
DOI: 10.1101/2024.10.18.619142

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