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Article

Cancer‐generated lactic acid: a regulatory, immunosuppressive metabolite?

31 May 2013

Abstract excerpt

The common preference of cancers for lactic acid-generating metabolic energy pathways has led to proposals that their reprogrammed metabolism confers growth advantages such as decreased susceptibility to hypoxic stress. Recent observations, however, suggest that it generates a novel way for cancer survival. There is increasing evidence that cancers can escape immune destruction by suppressing the anti-cancer...

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PMID: 23729358
DOI: 10.1002/path.4218

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