Article

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

2023-04-19

Abstract excerpt

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, PD-L1 expression on cancer cells is mainly regulated by IFN-γ, which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid...

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Literature Corpus work: 80ffe2ad-fa3d-559a-8a9f-7eedf10b94f0
DOI: 10.21203/rs.3.rs-2816652/v1

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