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Proton sensing GPCR’s: The missing link to Warburg’s oncogenic legacy?

8 Nov 2024

Abstract excerpt

A century after Otto Warburg's seminal discovery of aerobic glycolysis in cancer cells, a phenomenon dubbed the "Warburg effect", the mechanistic links between this metabolic rewiring and tumorigenesis remain elusive. Warburg postulated that this enhanced glucose fermentation to lactate, even in the presence of oxygen, stemmed from an "irreversible respiratory injury" intrinsic to cancer cells. While oxidative...

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PMID: 39641117
DOI: 10.46439/cancerbiology.5.066

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