Article

Contextual Tumor Suppressor Function of T Cell Death-Associated Gene 8 (TDAG8) in Hematological Malignancies

2017-06-01

Abstract excerpt

<h4>Key points</h4> 1. TDAG8 (GPR65) gene expression is down-regulated in hematological malignancies. 2. Restoration of TDAG8 gene expression in blood cancer cells suppresses tumor growth and metastasis. Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progressi...

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Literature Corpus work: 557d6e97-7f84-5d40-af5f-99b9908f152c
DOI: 10.1101/144725

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