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Mutations in C. elegans neuroligin-like glit-1 , the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

2017-10-13

Abstract excerpt

The loss of dopaminergic neurons is a hallmark of Parkinson’s disease, the aetiology of which is associated with increased levels of oxidative stress. We used C. elegans to screen for genes that protect dopaminergic neurons against oxidative stress and isolated glit-1 ( gli o t actin (Drosophila neuroligin-like) homologue) . Loss of the C. elegans neuroligin-like glit-1 causes increased dopaminergic neurode...

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Literature Corpus work: 98479ce0-a5b0-5820-82fc-71b2071565f7
DOI: 10.1101/203067

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Mutations in C. elegans neuroligin-like glit-1 , the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatmentDOI 10.1101/203067Read

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Mutations in <i>C. elegans</i> neuroligin-like <i>glit-1</i> , the apoptosis pathway and the calcium chaperone <i>crt-1</i> increase dopaminergic neurodegeneration after 6-OHDA treatment

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