Article

Snake venom-inspired novel peptides protect <i>Caenorhabditis elegans</i> against paraquat-induced Parkinson’s pathology

2024-06-01

Abstract excerpt

The in vivo protective mechanisms of two low molecular mass (∼1.4 kDa) novel custom peptides (CPs) against paraquat (PT)-induced neurodegenerative dysfunction in the Caenorhabditis elegans model were deciphered. CPs prevent the PT binding to the nerve ring adjacent to the pharynx in C. elegans (N2 strain) by stable and high-affinity binding to the tyrosine-protein kinase receptor CAM-1, resulting in significant...

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Literature Corpus work: 400040fd-d701-556b-bc80-d3bc0e157619
DOI: 10.1101/2024.06.01.596942

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