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Article

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.

The Journal of biological chemistry - 30 Dec 2005

Ved Rina, Saha Shamol, Westlund Beth, Perier Celine, Burnam Lucinda, Sluder Anne, Hoener Marius, Rodrigues Cecilia Mp, Alfonso Aixa, Steer Clifford, Liu Leo, Przedborski Serge, Wolozin Benjamin

Abstract excerpt

How genetic and environmental factors interact in Parkinson disease is poorly understood. We have now compared the patterns of vulnerability and rescue of Caenorhabditis elegans with genetic modifications of three different genetic factors implicated in Parkinson disease (PD). We observed that expressing alpha-synuclein, deleting parkin (K08E3.7), or knocking down DJ-1 (B0432.2) or parkin produces similar...

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Identifiers

PMID: 16239214
DOI: 10.1074/jbc.M505910200
PMCID: PMC3910375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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