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6-OHDA-induced dopaminergic neurodegeneration in <i>C. elegans</i> is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

2017-10-13

Abstract excerpt

Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson’s disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental factors. We screened for genes protecting Caenorhabditis elegans dopaminergic neurons from oxidative stress induced by the neurotoxin 6-hydroxydopamine (6-OHDA) and identified the...

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Literature Corpus work
2655bd40-24b5-52ea-9efb-6b3a2e4388c1
DOI
10.1101/198606
Open publication

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6-OHDA-induced dopaminergic neurodegeneration in <i>C. elegans</i> is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33DOI 10.1101/198606
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