Back to search

Article

Inhibition of mitochondrial complex III causes selective dopaminergic neurotoxicity by redox stress in <i>Caenorhabditis elegans</i>

2025-10-23

Abstract excerpt

Environmental factors including chemical exposures are important contributors to Parkinson’s disease (PD). Nearly all well-validated chemicals involved in PD affect mitochondria, and the great majority of those identified inhibit mitochondrial complex I, causing ATP depletion and oxidative stress. We hypothesized that inhibition of mitochondrial complex III would also cause dopaminergic neurotoxicity. Using Caeno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8d77d281-08e0-555c-82b9-5e73d48391c7
DOI
10.1101/2025.10.21.683798
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inhibition of mitochondrial complex III causes selective dopaminergic neurotoxicity by redox stress in <i>Caenorhabditis elegans</i>DOI 10.1101/2025.10.21.683798
Dopaminergic neuronal dysfunction induced by newer generation systemic insecticides in <i>Caenorhabditis elegans</i>Semantic proximity
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.Semantic proximity
Systematic Review of Caenorhabditis elegans Models for Mechanism Research and Drug Discovery in Parkinson’s DiseaseSemantic proximity
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Semantic proximity
Dopamine controls the Sensitivity to Manganese induced Dopaminergic neurotoxicity in <i>Caenorhabditis elegans</i>Semantic proximity
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseSemantic proximity
Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans modelsSemantic proximity
Investigating the Neuroprotective Effects of Vitamin E Against Oxidative Stress in the AWC Chemosensory Neurons of Caenorhabditis elegansSemantic proximity
C. elegans as a powerful model for neurotoxicity assessmentSemantic proximity
Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegansSemantic proximity
Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity.Semantic proximity
Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode <i>Caenorhabditis elegans</i>Semantic proximity
Select a neighboring publication to make it the new centre.