Article

Identification and characterization of mediators of toxicity of Aβ oligomers by genome wide screening in Caenorhabditis elegans

2017-01-01

Abstract excerpt

Soluble oligomers of the amyloid-β (Aβ) protein play a key role in the pathogenesis of Alzheimer’s disease (AD), although the underlying molecular mechanisms are poorly understood. In order to search for proteins involved in the formation and/or toxicity of Aβ oligomers, a transgenic C. elegans model of AD was used in which inducible expression of Aβ oligomers results in a complete paralysis; in these worms...

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Literature Corpus work: 38a03db1-5840-5faf-85e5-882a87dc6300
DOI: 10.21954/ou.ro.0000c46d

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