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Article

6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.

PLoS genetics - 1 Jan 2018

Offenburger Sarah-Lena, Ho Xue Yan, Tachie-Menson Theresa, Coakley Sean, Hilliard Massimo A, Gartner Anton

Abstract excerpt

Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson's disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental factors. We screened for genes protecting Caenorhabditis elegans dopaminergic neurons from oxidative stress induced by the neurotoxin 6-hydroxydopamine (6-OHDA) and identified the...

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Identifiers

PMID: 29346382
DOI: 10.1371/journal.pgen.1007125
PMCID: PMC5773127

Genes

TTR

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6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.PMID 29346382Read ↗

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