Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of<i>Caenorhabditis elegans</i>

Abstract excerpt

Parkinson's disease (PD) is linked genetically to proteins that function in the management of cellular stress resulting from protein misfolding and oxidative damage. Overexpression or mutation of alpha-synuclein results in the formation of Lewy bodies and neurodegeneration of dopaminergic (DA) neurons. Human torsinA, mutations in which cause another movement disorder termed early-onset torsion dystonia, is highly...

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