Article

Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand

2025-04-02

Abstract excerpt

<h4>SUMMARY</h4> The human nephron is a highly patterned tubular structure. It develops specialized cells that regulate bodily fluid homeostasis, blood pressure, and urine secretion throughout life. Approximately 1 million nephrons form in each kidney during embryonic and fetal development, but how they develop is poorly understood. Here we interrogate axial patterning mechanisms in the human nephron using an iPS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 982cc109-ff55-57e1-8a8e-8c9739e471bf
DOI: 10.1101/2025.03.29.646044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on DemandDOI 10.1101/2025.03.29.646044Read

Axial nephron fate switching demonstrates a plastic system tunable on demandSemantic proximity Read

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting OrganizersSemantic proximity Read

Spatial Transcriptional Mapping of the Human Nephrogenic ProgramSemantic proximity Read

Stepwise developmental mimicry generates proximal-biased kidney organoidsSemantic proximity Read

Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transitionSemantic proximity Read

Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fateSemantic proximity Read

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron PatterningSemantic proximity Read

<i>In vitro</i> plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signalsSemantic proximity Read

Single-cell analysis of progenitor cell dynamics and lineage specification of the human fetal kidneySemantic proximity Read

Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate DecisionsSemantic proximity Read

A coordinated progression of progenitor cell states initiates urinary tract developmentSemantic proximity Read

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoidsSemantic proximity Read