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Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate

21 Jul 2025

Abstract excerpt

Abstract Pluripotent stem cell (PSC)–derived kidney organoids are used to model human renal development and disease; however, accessible models of human fetal development to benchmark PSC-derived organoids remain underdeveloped. Here, we establish a chemically defined, serum-free protocol for prolonged culture of human fetal kidney-derived organoids (hFKOs) in vitro. hFKOs self-organize into polarized renal...

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PMID: 40691416
DOI: 10.1038/s44318-025-00504-2

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