Article

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

2023-05-25

Abstract excerpt

<h4>SUMMARY</h4> Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Here we report manipulation of p38 and YAP activity creates a synthetic niche that allows the long-term clonal expansion of primary mouse and human NPCs, and induced NPCs (iNPCs) from human pluripotent stem cells. Cultured iNPCs resemble closely primary human NPCs, generating nephron or...

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Literature Corpus work: 76c3a806-379c-54a3-8593-6c159180d70b
DOI: 10.1101/2023.05.25.542343

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