Article

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers

2024-11-30

Abstract excerpt

Current human pluripotent stem cell-derived kidney organoids contain nephron-like structures that lack organotypic patterning. It is thought that during human development, nephrons form their proximal-distal axial polarity in response to collecting duct-derived signals that are absent in kidney organoids. To delineate how nephron polarities establish, we profiled human kidney development by spatial transcriptomic...

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Literature Corpus work: 65f152d9-6f2f-584b-937c-516fbc8d7874
DOI: 10.1101/2024.11.30.626171

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