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Axial nephron fate switching demonstrates a plastic system tunable on demand

25 Aug 2025

Abstract excerpt

The human nephron is a highly patterned tubular structure that develops specialized cells to regulate bodily fluid homeostasis, blood pressure, and urine secretion throughout life. Approximately 1 million nephrons form in each kidney during embryonic and fetal development, but how they develop is poorly understood. Here, we interrogate axial patterning mechanisms in the human nephron using an iPSC-derived kidney...

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PMID: 40855070
DOI: 10.1038/s41467-025-63290-9

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