Article

Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions

2025-06-20

Abstract excerpt

Cell-cell interactions play a pivotal role in organ development, yet these communications have previously been studied one interaction at a time in model organisms, leaving a gap in our understanding of the cellular interplay in human development. To address this, we investigated human kidney development using single-cell RNA sequencing and spatial transcriptomics, analyzing over 500,000 cells. By mapping gene exp...

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Literature Corpus work: aef2a5c7-a2a0-58d1-9e8a-3f2138a16186
DOI: 10.1101/2025.06.15.659579

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