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Article

Stepwise developmental mimicry generates proximal-biased kidney organoids

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> The kidney maintains body fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for renal reabsorption of a range of sugars, ions, and amino acids, are highly susceptible to damage, leading to pathologies necessitating dialysis and kidney transplants. While human pluripotent stem cell-derived kidney organoids are used for modeling renal developm...

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Literature Corpus work
ff80c948-3efe-558a-95d4-91de0bed85e2
DOI
10.1101/2024.06.28.601028
Open publication

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