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Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer

2025-06-17

Abstract excerpt

<h4>Summary</h4> Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense extracellular matrix (ECM) that sustains an immunosuppressive tumor microenvironment (TME). While this protective niche has been described, the molecular determinants orchestrating its formation and dictating its immune interactions are not well defined. Using Perturb-map, we determine how dozens of different gene perturbations s...

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Literature Corpus work
97e0cd1a-5e43-5c89-8fd5-5a1c6ad98eba
DOI
10.1101/2025.06.11.659098
Open publication

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