Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

27 Mar 2017

Abstract excerpt

Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity. SerpinB2 expression, particularly in the stromal compartment, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (PDAC) and our genomic analysis revealed that SERPINB2 is frequently deleted in PDAC. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Pancreatic and Hepatic Oncology Research
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28346421
DOI: 10.1038/onc.2017.63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancerPMID 28346421Read ↗

Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancerSemantic proximity Read ↗

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).Semantic proximity Read ↗

Stromal SPOCK 1 supports invasive pancreatic cancer growthSemantic proximity Read ↗

The extracellular matrix in cancer: from understanding to targetingSemantic proximity Read ↗

Stromal biology of pancreatic cancerSemantic proximity Read ↗

Transcriptome analysis of SerpinB2-deficient breast tumors provides insight into deciphering SerpinB2-mediated roles in breast cancer progressionSemantic proximity Read ↗

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and functionSemantic proximity Read ↗

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cellsSemantic proximity Read ↗

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

A targetable opioid/cancer associated fibroblast axis drives extracellular matrix remodeling and tumor aggressiveness in pancreatic cancerSemantic proximity Read ↗

Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells.Semantic proximity Read ↗

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.