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Article

Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU).

Frontiers in immunology - 1 Jan 2022

Hosen S M Zahid, Uddin Md Nazim, Xu Zhihong, Buckley Benjamin J, Perera Chamini, Pang Tony C Y, Mekapogu Alpha Raj, Moni Mohammad Ali, Notta Faiyaz, Gallinger Steven, Pirola Ron, Wilson Jeremy, Ranson Marie, Goldstein David, Apte Minoti

Abstract excerpt

Background: Previous studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU) expression and activity in several pathways associated with cancer progression. However, systematic investigation into the association of PLAU expression with factors that modulate PDAC (pancreatic ductal adenocarcinoma) progression is lacking, such as those affecting stromal (pancreatic stellate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36591282
DOI: 10.3389/fimmu.2022.1060957
PMCID: PMC9794594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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