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Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcome

2025-02-10

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC), accounting for 90% of pancreatic neoplasms, is characterized by its poor prognosis, with a 5-year survival rate of only 12%. Most patients are diagnosed with metastatic or locally advanced disease, leaving only 15% eligible for curative resection. PDAC exhibits resistance to chemotherapy, targeted therapies, and immunotherapy, largely due to its highly heterogeneous tumor m...

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Literature Corpus work
e59abcda-00b7-5680-9fbb-92125ab9a04c
DOI
10.1101/2025.02.08.637283
Open publication

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Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeDOI 10.1101/2025.02.08.637283
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