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Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progression

25 Aug 2025

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, largely due to its highly immunosuppressive and fibrotic tumor microenvironment (TME). However, the spatial and functional organization of its cellular components remains poorly understood. METHODS: We present an integrated transcriptomic atlas of the PDAC TME by combining single-cell RNA sequencing (n = 88; 187,520...

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PMID: 40855036
DOI: 10.1007/s13402-025-01100-6

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