Back to search

Article

A comprehensive transcriptional signature in pancreatic ductal adenocarcinoma reveals new insights into the immune and desmoplastic microenvironment

2023-04-03

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) prognosis and treatment response remains devastatingly poor due partly to the highly heterogeneous, aggressive, and immunosuppressive nature of this tumor type. The intricate relationship between stroma, inflammation, and immunity remains vaguely understood in the PDAC microenvironment. Here, we performed a meta-analysis of stroma-, and immune-related gene expression in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f5e20104-4b40-52de-abdb-41c0dfa9a3d8
DOI
10.1101/2023.03.31.535058
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A comprehensive transcriptional signature in pancreatic ductal adenocarcinoma reveals new insights into the immune and desmoplastic microenvironmentDOI 10.1101/2023.03.31.535058
Immunophenotypes of pancreatic ductal adenocarcinoma: Meta‐analysis of transcriptional subtypesSemantic proximity
Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDACSemantic proximity
Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity
A 15-Gene Immune, Stromal, and Proliferation Gene Signature that Significantly Associates with Poor Survival in Patients with Pancreatic Ductal AdenocarcinomaSemantic proximity
Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Metaanalysis of transcriptional subtypesSemantic proximity
Prognostic Significance and Immune Infiltration of Microenvironment‐related Signatures in Pancreatic CancerSemantic proximity
Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity
Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeSemantic proximity
Molecular Pathway and Immune Profile Analysis of IPMN-Derived versus PanIN-Derived Pancreatic Ductal AdenocarcinomasSemantic proximity
Dysregulated miRNAs modulate tumor microenvironment associated signaling networks in pancreatic ductal adenocarcinomaSemantic proximity
Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencingSemantic proximity
Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance.Semantic proximity
Select a neighboring publication to make it the new centre.