Article

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progression

2025-02-15

Abstract excerpt

<h4>Background</h4> Pancreatic ductal adenocarcinoma (PDAC) features a complex tumor microenvironment (TME) that significantly influences patient outcomes. Understanding the TME’s cellular composition and interactions is crucial for identifying therapeutic targets to improve treatment. <h4>Methods</h4> We performed an integrative analysis combining 88 single-cell RNA sequencing (scRNA-seq) samples with 187,520 c...

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Literature Corpus work: 66da96d2-e15b-5c05-9fae-1df38fe373fb
DOI: 10.1101/2025.02.11.637627

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