Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritance

11 Feb 2025

Abstract excerpt

Maternal inheritance of mitochondrial DNA (mtDNA) is highly conserved in metazoans. While many species eliminate paternal mtDNA during late sperm development to foster maternal inheritance, the regulatory mechanisms governing this process remain elusive. Through a forward genetic screen in Drosophila, we identified 47 mutant lines exhibiting substantial retention of mtDNA in mature sperm. We mapped one line to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic diversity and population structure
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39934413
DOI: 10.1038/s44318-025-00378-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritancePMID 39934413Read ↗

Fndc-1 contributes to paternal mitochondria elimination in C. elegansSemantic proximity Read ↗

Roles for Drp1, a dynamin-related protein, and milton, a kinesin-associated protein, in mitochondrial segregation, unfurling and elongation during Drosophila spermatogenesis.Semantic proximity Read ↗

Adenine nucleotide translocase 2 ( Ant2 ) is required for individualization of spermatogenesis of Drosophila melanogasterSemantic proximity Read ↗

A structure-selective endonuclease drives uniparental mitochondrial DNA inheritanceSemantic proximity Read ↗

Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila.Semantic proximity Read ↗

The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesisSemantic proximity Read ↗

Paralog-dependent Specialization of Paf1C subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in DrosophilaSemantic proximity Read ↗

Spermitin: a novel mitochondrial protein in Drosophila spermatids.Semantic proximity Read ↗

Histone removal in sperm protects paternal chromosomes from premature division at fertilizationSemantic proximity Read ↗

A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic RemodelingSemantic proximity Read ↗

Mitochondrial curation for the next generation.Semantic proximity Read ↗

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.