Article

Transfer of mitochondrial DNA into the nuclear genome during gene editing

2023-07-20

Abstract excerpt

Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear g...

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Literature Corpus work: c5e813cf-df8b-5052-ab66-df90d2378bf3
DOI: 10.1101/2023.07.19.549443

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