Article

Microhomology-Mediated Circular DNA Formation from Oligonucleosomal Fragments During Spermatogenesis

2023-03-01

Abstract excerpt

The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis. We noted that germline eccDNAs are derived from oligonucleosomal DNA fragmentation in cells likely undergoing cell death, providing a potential new way for quality assessment of...

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Literature Corpus work: ac4f0367-e3c5-58a5-918f-d1adec2a07ce
DOI: 10.1101/2023.02.27.530352

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