Article
The use of mitochondria-targeted endonucleases to manipulate mtDNA.
Methods in enzymology - 1 Jan 2014
Bacman Sandra R, Williams Sion L, Pinto Milena, Moraes Carlos T
Abstract excerpt
For more than a decade, mitochondria-targeted nucleases have been used to promote double-strand breaks in the mitochondrial genome. This was done in mitochondrial DNA (mtDNA) homoplasmic systems, where all mtDNA molecules can be affected, to create models of mitochondrial deficiencies. Alternatively, they were also used in a heteroplasmic model, where only a subset of the mtDNA molecules were substrates for...
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