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Article

Mitochondrial curation for the next generation.

Current opinion in genetics & development - 1 Aug 2025

Gundberg Gregory C, Nance Jeremy

Abstract excerpt

The mitochondrial genome (mtDNA) can accumulate deleterious mutations that lead to disease. Animals have evolved strategies to eliminate mtDNA mutations in the maternal germ line, increasing the likelihood that their progeny inherit healthy mitochondria. Here, we provide an overview of mitochondrial quality control in the germ line, focusing on recent findings in mammals, Drosophila, and C. elegans. We discuss...

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Identifiers

PMID: 40617230
DOI: 10.1016/j.gde.2025.102376
PMCID: PMC12277965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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