Article
Avoiding Extinction: Recent Advances in Understanding Mechanisms of Mitochondrial DNA Purifying Selection in the Germline.
Annual review of genomics and human genetics - 31 Aug 2021
Jeedigunta Swathi P, Minenkova Anastasia V, Palozzi Jonathan M, Hurd Thomas R
Abstract excerpt
Mitochondria are unusual organelles in that they contain their own genomes, which are kept apart from the rest of the DNA in the cell. While mitochondrial DNA (mtDNA) is essential for respiration and most multicellular life, maintaining a genome outside the nucleus brings with it a number of challenges. Chief among these is preserving mtDNA genomic integrity from one generation to the next. In this review, we...
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