Article
Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck.
PLoS biology - 1 Apr 2021
Edwards David M, Røyrvik Ellen C, Chustecki Joanna M, Giannakis Konstantinos, Glastad Robert C, Radzvilavicius Arunas L, Johnston Iain G
Abstract excerpt
Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic "bottleneck" increases cell-to-cell variance in mtDNA heteroplasmy, allowing purifying selection to act to maintain low proportions of mutant mtDNA. However, most eukaryotes do not sequester a germline early...
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