Article

Engineering targeted deletions in the mitochondrial genome

2018-03-22

Abstract excerpt

<h4>Summary Paragraph</h4> Mitochondria are a network of critical intracellular organelles with diverse functions ranging from energy production to cell signaling. The mitochondrial genome (mtDNA) consists of 37 genes that support oxidative phosphorylation and are prone to dysfunction that can lead to currently untreatable diseases. Further characterization of mtDNA gene function and creation of more accurate mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a86dd83-a76e-563a-b9da-262dc70cc5b5
DOI: 10.1101/287342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering targeted deletions in the mitochondrial genomeDOI 10.1101/287342Read

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.Semantic proximity Read

The use of mitochondria-targeted endonucleases to manipulate mtDNA.Semantic proximity Read

A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using ZebrafishSemantic proximity Read

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.Semantic proximity Read

Precise modelling of mitochondrial diseases using optimized mitoBEs.Semantic proximity Read

A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafishSemantic proximity Read

Tools for editing the mammalian mitochondrial genome.Semantic proximity Read

Development of mitochondrial gene-editing strategies and their potential applications in mitochondrial hereditary diseases: a review.Semantic proximity Read

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scopeSemantic proximity Read

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.Semantic proximity Read

Engineering mtDNA Deletions by Reconstituting End-Joining in Human MitochondriaSemantic proximity Read

Therapeutic potential of engineering the mitochondrial genome.Semantic proximity Read