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Human APOBEC3 Variations and Viral Infection

14 Jul 2021

Abstract excerpt

Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes are capable of inhibiting a wide range of endogenous and exogenous viruses using deaminase and deaminase-independent mechanisms. These enzymes are essential components of our innate immune system, as evidenced by (a) their strong positive selection and expansion in primates, (b) the evolution of viral counter-defense mechanisms,...

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PMID: 34372572
DOI: 10.3390/v13071366

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