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Article

Recurrent Loss of APOBEC3H Activity during Primate Evolution.

Journal of virology - 1 Sept 2018

Garcia Erin I, Emerman Michael

Abstract excerpt

Genes in the APOBEC3 family encode cytidine deaminases that provide a barrier against viral infection and retrotransposition. Of all the APOBEC3 genes in humans, APOBEC3H (A3H) is the most polymorphic: some genes encode stable and active A3H proteins, while others are unstable and poorly antiviral. Such variation in human A3H affects interactions with the lentiviral antagonist Vif, which counteracts A3H via...

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Identifiers

PMID: 29925657
DOI: 10.1128/JVI.00971-18
PMCID: PMC6096791

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