Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.

Cell host & microbe - 19 Jan 2012

Compton Alex A, Hirsch Vanessa M, Emerman Michael

Abstract excerpt

APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its degradation. This Vif-mediated A3G inhibition is species specific, suggesting that the A3G-Vif interaction has evolved as primate lentiviruses have adapted to their hosts. We examined the evolutionary dynamics of the A3G-Vif interaction within four African...

Topics

Join the communities discussing this publication.

Asymptomatic Diseases
Chlorocebus aethiops
Cluster Analysis
Cytidine Deaminase
Gene Products, vif

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 22264516
DOI: 10.1016/j.chom.2011.11.010
PMCID: PMC3266539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.PMID 22264516Read ↗

Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.Semantic proximity Read ↗

APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate HostSemantic proximity Read ↗

HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors.Semantic proximity Read ↗

Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate LentivirusesSemantic proximity Read ↗

HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursorsSemantic proximity Read ↗

A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.Semantic proximity Read ↗

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.Semantic proximity Read ↗

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present.Semantic proximity Read ↗

Rapid evolution of primate antiviral enzyme APOBEC3G.Semantic proximity Read ↗

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to HumansSemantic proximity Read ↗

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.Semantic proximity Read ↗

Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.