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Article

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.

PLoS genetics - 1 Nov 2014

Refsland Eric W, Hultquist Judd F, Luengas Elizabeth M, Ikeda Terumasa, Shaban Nadine M, Law Emily K, Brown William L, Reilly Cavan, Emerman Michael, Harris Reuben S

Abstract excerpt

The Vif protein of HIV-1 allows virus replication by degrading several members of the host-encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host APOBEC3 genes and the viral vif gene have the potential to impact the extent of virus replication among individuals. The most genetically diverse of the seven human APOBEC3 genes is APOBEC3H with seven known haplotypes. Overexpression studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 25411794
DOI: 10.1371/journal.pgen.1004761
PMCID: PMC4238949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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