Article

Whole-Brain Cell-Cell Interaction Axes Explaining Tissue Vulnerability Across the Neurodegenerative Spectrum

2025-07-24

Abstract excerpt

Disrupted cell-cell communication represents a fundamental mechanism underlying neurodegeneration, yet how specific intercellular signaling patterns relate to regional brain vulnerability remains poorly understood. Here, we map whole-brain intercellular interaction networks and their spatial correspondence with tissue damage across 13 neurodegenerative conditions, including early– and late-onset Alzheimer’s diseas...

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Literature Corpus work: de7bb34b-283a-53cc-9699-e2c36425e15b
DOI: 10.1101/2025.07.21.665217

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