Article

Proteomic Subtyping of Alzheimer’s Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers

2025-03-15

Abstract excerpt

Alzheimer’s disease (AD) is characterized by significant clinical and molecular heterogeneity, influenced by genetic and demographic factors. Using an unbiased, network-driven approach, we analyzed the cerebrospinal fluid (CSF) proteome from 431 individuals (483 samples), including 111 African American participants, to identify core protein modules associated with AD, race, sex, and age. Our analysis revealed ten...

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Literature Corpus work: 2fbba4ee-31c7-507c-bb75-f9b33541de37
DOI: 10.1101/2025.03.14.643332

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