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Article

Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.

Brain : a journal of neurology - 1 Sept 2018

Grothe Michel J, Sepulcre Jorge, Gonzalez-Escamilla Gabriel, Jelistratova Irina, Schöll Michael, Hansson Oskar, Teipel Stefan J

Abstract excerpt

Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically affect discrete neuronal systems, but the underlying mechanisms that render some brain regions more vulnerable to Alzheimer's disease pathology than others remain largely unknown. Here we studied molecular properties underlying these distinct regional vulnerabilities by analysing Alzheimer's disease-typical neuroimaging...

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Identifiers

PMID: 30016411
DOI: 10.1093/brain/awy189
PMCID: PMC6113636

Genes

MAPT
APP
CDK5
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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