Article

Transcriptomic signatures of Aβ- and tau-induced neuronal dysfunction reveal inflammatory processes at the core of Alzheimer’s disease pathophysiology

2023-09-15

Abstract excerpt

Molecular mechanisms enabling pathology-induced neuronal dysfunction in Alzheimer’s disease (AD) remain elusive. Here, we use mechanistic computational models to infer the combined influence of PET-measured Aβ and tau burdens on fMRI-derived neuronal activity and to subsequently identify the transcriptomic spatial correlates of AD pathophysiology. Our results reveal overrepresented genes and biological processes t...

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Literature Corpus work: 3cc8af8e-f2ba-5705-a5f9-32275aa63724
DOI: 10.1101/2023.09.15.557737

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