Article

Genetic integration with cell-specific nucleosome positioning resolves causal relationships underlying chromatin accessibility profiles

2025-09-13

Abstract excerpt

Cell type-specific chromatin accessibility QTL (caQTL) mapping is a promising approach to understand genetic control of chromatin landscapes and identify regulatory mechanisms underlying GWAS associations. However, current caQTL studies lack resolution and do not distinguish nucleosome-free regions (NFR) from positioned nucleosomes. Here, we leverage statistical modeling of fragment position and length to decompos...

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Literature Corpus work: 248bd23f-2207-54e1-a621-2fed177873d1
DOI: 10.1101/2025.09.09.674883

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