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Article

Extensive differential gene expression and regulation by sex in human skeletal muscle

5 Jun 2025

Abstract excerpt

The identification of sex-differential gene regulatory elements is essential for understanding sex-differential patterns of health and disease. We leveraged bulk and single-nucleus RNA sequencing (RNA-seq) and single-nucleus ATAC-seq data from 281 skeletal muscle biopsies to characterize sex differences in gene expression and regulation at the cell-type and whole-tissue levels. We found highly concordant...

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PMID: 40480217
DOI: 10.1016/j.xgen.2025.100915

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