Article

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

2020-07-28

Abstract excerpt

Tumor progression and metastatic dissemination are driven by cell-intrinsic and biomechanical cues that favor the growth of life-threatening secondary tumors. We recently identified prometastatic vascular regions with blood flow profiles that are permissive for the arrest of circulating tumor cells. We have further established that such flow profiles also control endothelial remodeling, which favors extravasation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9760a586-52c5-5fcc-899d-76500a8c6ede
DOI: 10.1101/2020.07.27.219568

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cellsDOI 10.1101/2020.07.27.219568Read

Tunable Laminar Perfusion Coordinates Endothelial and Perivascular Remodeling in Angiogenic Vasculature-on-ChipSemantic proximity Read

Microfluidic vascular models of tumor cell extravasationSemantic proximity Read

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model.Semantic proximity Read

Mechano-Initiated PIEZO1-VEGFR2 Interaction Governs CD34 <sup>+</sup> Cell Differentiation and Repair in Arteriovenous FistulaSemantic proximity Read

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues and limits ribosomal biogenesisSemantic proximity Read

Positive-feedback defines the timing and robustness of angiogenesisSemantic proximity Read

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.Semantic proximity Read

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27Semantic proximity Read

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stressSemantic proximity Read

Physiological perfusion of human vasculature reveals a YAP/TAZ-Apelin switch linking intraluminal flow to endothelial state transitions and vessel remodelingSemantic proximity Read

Integrating Vascular Phenotypic and Proteomic Analysis in an Open Microfluidic Platform.Semantic proximity Read

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions.Semantic proximity Read