Article

Positive-feedback defines the timing and robustness of angiogenesis

2018-07-22

Abstract excerpt

<h4>SUMMARY</h4> Blood vessel formation by angiogenesis is critical for tissue development, homeostasis and repair, and is frequently dysregulated in disease[1–3]. Angiogenesis is triggered by vascular endothelial growth factor receptor-2/3 (VEGFR) signalling, which induces motile endothelial cell (ECs) tip identity[4,5]. Tip cells lead new branching vessels, but also coordinate collective EC movement by repressi...

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Literature Corpus work: 91db23a0-efb7-52ce-bd5a-a1179e09e110
DOI: 10.1101/374389

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