Article

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues and limits ribosomal biogenesis

2024-05-24

Abstract excerpt

<title>Abstract</title> <p>Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead to blood vessel diameter expansion, while decreases in blood flow cause blood vessel narrowing. Aberrations in blood vessel diameter control can cause congenital arteriovenous malformations (AVMs). We show in zebrafish embryos that while arteries behave according to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36a1fc2b-9f30-57fd-933d-0bf959841ed3
DOI: 10.21203/rs.3.rs-4421247/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues and limits ribosomal biogenesisDOI 10.21203/rs.3.rs-4421247/v1Read

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues.Semantic proximity Read

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.Semantic proximity Read

Interaction between alk1 and blood flow in the development of arteriovenous malformationsSemantic proximity Read

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stressSemantic proximity Read

Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.Semantic proximity Read

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read

Gene-specific endothelial programs drive AVM pathogenesis in SMAD4 and ALK1 loss-of-functionSemantic proximity Read

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read

Blood flow regulates <i>acvrl1</i> transcription via ligand-dependent Alk1 activitySemantic proximity Read

PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformationsSemantic proximity Read

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2Semantic proximity Read

MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.Semantic proximity Read