Article

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress

2024-12-02

Abstract excerpt

Blood vessels in mammalian embryos develop from initial aggregates of endothelial cell (EC) progenitors, which coordinate the opening and stabilization of central vascular lumens, all while under progressively increasing flow and pressure from blood circulation. Mechanical cues exerted by shear stress from the blood flow remodel an initial vascular plexus into a ramifying array of large and small vessels. As plasm...

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Literature Corpus work: 131a7d4a-52cf-5985-9b4a-92c714f120b9
DOI: 10.1101/2024.12.01.626284

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